Mental wellness is not just about positive thinking or willpower, but rather rooted in the complex interplay of biochemistry, hormones, nervous system function, and cellular health. According to research done by the National Alliance on Mental Illness (NAMI), approximately 1 in 5 American adults experiences some form of mental illness each year, and more than 1 in 20 experience “serious” mental illness.1
At The Longevity Centers, we believe that many manifestations of anxiety, depression, brain fog, burnout, and trauma-related symptoms often have physiological origins. These may call for looking beyond symptoms to the underlying physiology.
Our integrative mental wellness therapies address the root causes of psychological distress by targeting nervous system dysregulation, hormonal imbalances, chronic inflammation, and cellular dysfunction. Whether you are managing trauma responses, navigating the fog of chronic stress, or seeking to optimize cognitive performance and emotional resilience, our therapies are designed to address these factors as part of a broader care plan.
The table below summarizes the five therapies covered on this page:
| Therapy | Primary Target | Delivery Method |
|---|---|---|
| Stellate ganglion block (SGB) | Overactive fight-or-flight (sympathetic) nervous system | Ultrasound-guided local anesthetic injection in the neck |
| Procaine IV therapy | Autonomic imbalance and systemic inflammation | Intravenous infusion, typically about 60 minutes |
| EBOOST™ IV ozone therapy | Chronic inflammation and cellular energy | Extracorporeal blood oxygenation and ozonation (EBOO) |
| Hormone therapy for men | Testosterone and related hormone imbalances | Bioidentical hormones by patch, pill, troche or injection |
| Hormone therapy for women | Estrogen and progesterone imbalances | Bioidentical hormones by patch, pill, troche or injection |
The Whole-Body Approach to Mental Health
Conventional mental health care often centers on medication and talk therapy, and both can be valuable. Hormones, inflammation and nervous system function can also play a role in how you feel.
Your mood, cognitive function, and emotional regulation depend on far more than what is happening in your brain. Hormone imbalances can trigger anxiety and depression. Chronic inflammation affects neurotransmitter production and brain function.2 Toxin accumulation impairs cellular energy production and mental clarity. Nervous system dysregulation keeps you trapped in fight-or-flight mode, making calm and clarity impossible.
When these underlying biological issues remain unaddressed, mental health symptoms usually persist, despite best efforts with traditional approaches. Our therapies are designed to address these factors alongside your other care.
Therapies for Mental Wellness
Stellate Ganglion Block (SGB): Resetting the Trauma Response
When you experience trauma or chronic stress, your sympathetic nervous system can become stuck in overdrive. The stellate ganglion, a collection of nerve cells in your neck, plays a key role in maintaining this hypervigilant state.3
The stellate ganglion block (SGB) represents a newer approach to trauma-related symptoms with growing research interest.4 This precisely targeted nerve block injection is designed to calm the overactive sympathetic nervous system, the part of your nervous system responsible for the fight-or-flight response. By temporarily blocking signals through this ganglion with a local anesthetic injection, the goal is to essentially “reboot” your nervous system and restore normal function.
What the Research Shows
A multisite, randomized clinical trial published in JAMA Psychiatry found that, among more than 100 active-duty service members, two SGB treatments given two weeks apart reduced PTSD symptom severity over eight weeks compared with a sham procedure. The researchers recommended further study of SGB as an adjunct to PTSD treatment.5
Potential stellate ganglion block benefits for mental wellness:
- May help reduce PTSD and trauma-related symptoms
- May help with hypervigilance and hyperarousal
- May improve sleep
The procedure itself takes only minutes and is performed with ultrasound guidance for precision and safety. Some patients receive a single block and others a series, depending on their response.
What makes SGB therapy particularly valuable is its ability to break the cycle of nervous system dysregulation that keeps you trapped in chronic stress and anxiety. By calming the sympathetic overdrive, stellate ganglion block can create a physiological foundation that makes other mental health interventions—including therapy, meditation, and lifestyle changes—more effective for some patients.
Learn More About Stellate Ganglion Block
Your licensed provider will go over the risks with you.
Procaine IV Therapy: A Gentle Nervous System Reset
Procaine IV therapy offers a powerful approach to calming an overstimulated nervous system and restoring emotional balance. This intravenous therapy delivers procaine—a local anesthetic with unique nervous system-regulating properties—directly into your bloodstream. Here, it works to reset autonomic function and reduce systemic inflammation that contributes to mental health symptoms.6
Potential procaine IV therapy benefits for mental wellness:
- Reduced anxiety and inner tension that conventional treatments have not resolved
- Calmer mood and improved emotional regulation
- Enhanced sleep quality—falling asleep faster and achieving deeper rest
- Relief from the “stuck in stress mode” feeling (that so often characterizes chronic anxiety)
- Decreased physical tension and muscle guarding associated with mental stress
- Improved ability to engage with therapy and other healing modalities
What to Expect
The infusion typically takes 60 minutes and is administered in a comfortable, relaxing environment. Most patients find the therapy pleasant and use the time to rest, read, or simply allow their nervous system to downregulate. Many patients incorporate procaine IV therapy as part of their ongoing mental wellness maintenance, using periodic infusions to support nervous system resilience during high-stress periods.
Learn More About Procaine IV Therapy
Your licensed provider will go over the risks with you.
IV Ozone Therapy (EBOOST™)
Some research suggests chronic inflammation may play a role in fatigue, brain fog and mood. EBOO is a procedure where blood is drawn, filtered, exposed to oxygen and ozone in a closed loop, and returned to the body. EBOOST™ is our proprietary EBOO protocol, developed by Dr. Benjamin Kosubevsky, D.O.
A fuller explanation of how the protocol works is available on our extracorporeal blood oxygenation therapy page.
Learn More About IV Ozone Therapy
Your licensed provider will go over the risks with you.
Potential EBOOST™ IV ozone therapy benefits for mental wellness include:
- Relief from mental fatigue and brain fog that clouds thinking
- Reduced chronic inflammation that contributes to depression and anxiety
- Improved mood swings and emotional instability
- Support for immune function and mitochondrial health, which are crucial for brain energy
- Increased mental clarity, focus, and cognitive sharpness
- Enhanced overall energy and motivation
- Better stress resilience and emotional regulation
Hormone Therapy for Men: Restoring Mental Balance Through Testosterone Optimization
Hormones profoundly influence mental health, yet hormonal causes of anxiety, depression, and cognitive decline are frequently overlooked, especially in men.7 Hormone therapy for men focuses on optimizing testosterone and related hormones to improve mood stability, mental clarity, focus, and emotional resilience.
Low testosterone does not just affect physical vitality and sexual function, it has significant mental and emotional consequences. Men with suboptimal testosterone levels frequently experience depression, irritability, anxiety, brain fog, reduced motivation, and difficulty managing stress.
Hormones and Cognitive Function
Beyond mood, testosterone influences cognitive function, particularly executive functions like decision-making, focus, and mental flexibility. These symptoms are often misdiagnosed as primary psychiatric conditions when they are actually manifestations of hormonal imbalance.
Potential benefits of hormone therapy for men:
- Reduced irritability, mood swings, and emotional instability
- Helps with anxiety and depression that has not responded to conventional treatment
- Improved brain fog, mental clarity, and cognitive sharpness
- Increased motivation, drive, and goal-directed behavior
- Enhanced stress resilience and emotional regulation
- Improved sleep quality (crucial for mental health)
- Support confidence and overall sense of well-being
Our Approach
Therapy typically involves bioidentical hormone replacement delivered through injections, patches, pills or troches, depending on your preferences and physiology. We monitor your response closely and adjust protocols to achieve optimal mental and physical outcomes while minimizing side effects.
Our approach to hormone therapy for men goes beyond simply prescribing testosterone. We conduct comprehensive hormone testing to assess testosterone, estrogen, thyroid hormones, cortisol, and other factors that influence mental wellness.
These results can help show whether hormonal factors may be contributing to mood or cognitive symptoms. Learn more about hormone testing at The Longevity Centers.
Learn More About Hormone Therapy for Men
Your licensed provider will go over the risks with you.
Hormone Therapy for Women: Balancing the Mind Through Hormonal Harmony
Hormonal influences on women’s mental health begin in adolescence and continue through perimenopause and beyond. Premenstrual dysphoric disorder (PMDD), postpartum depression, perimenopausal anxiety and depression, and cognitive changes during menopause all demonstrate how powerfully hormones affect psychological well-being.
For women, the connection between hormones and mental wellness is undeniable. Fluctuations in estrogen, progesterone, and other hormones can directly influence neurotransmitter production, stress response, sleep quality, and emotional regulation. When hormone imbalance is a factor, hormone therapy may help with mood, anxiety, sleep and mental clarity.
How Estrogen and Progesterone Affect Mood
Estrogen influences serotonin production and receptor sensitivity, which is why many women notice mood changes correlating with their menstrual cycle or during perimenopause when estrogen fluctuates dramatically. Progesterone has calming, anxiolytic effects through its influence on GABA receptors in the brain.8 When these hormones become imbalanced, anxiety, depression, irritability, and mental fog often result.
Potential hormone therapy benefits for women:
- Reduced anxiety and emotional reactivity that disrupts daily life
- Improved mental clarity, focus, and cognitive function
- Better sleep quality and easier stress coping
- More stable mood
- Relief from brain fog and memory issues associated with hormonal changes
- Reduced irritability and emotional sensitivity
Our Approach
Our hormone therapy for women protocols are highly individualized, accounting for your age, menstrual status, symptoms, and hormone levels. We use bioidentical hormones that match your body’s natural hormones, delivered through patches, pills, troches or injections, depending on your needs and preferences. We don’t use pellets. Once a pellet is placed, the dose can’t be adjusted, and placing it is an invasive procedure. Patches, pills, troches and injections let your licensed provider fine-tune your dose over time.
Importantly, we also address environmental toxins and heavy metals that act as endocrine disruptors, interfering with your natural hormone balance. Our protocols often include chelation therapy to remove these hormone-disrupting substances, allowing your endocrine system to function optimally.
Learn More About Hormone Therapy for Women
Your licensed provider will go over the risks with you.
Combining Therapies for Comprehensive Mental Wellness
Many patients have more than one contributing factor. Your licensed provider may recommend one therapy or a combination, such as hormone therapy with SGB, based on your labs and history.
When Traditional Mental Health Treatment Isn’t Enough
If you have tried talk therapy, antidepressants, anti-anxiety medications, or other conventional approaches without achieving the results you hoped for, you are not alone. Many of our patients spent years working with psychiatrists and therapists, trying multiple medications and therapeutic modalities, yet still struggled with persistent symptoms.
The missing piece is often physiological. When hormone imbalances keep your mood dysregulated, when chronic inflammation impairs neurotransmitter function, when toxins interfere with cellular energy production, or when your nervous system remains stuck in fight-or-flight mode, addressing these biological factors becomes essential.
To be clear: our therapies do not replace good therapy or appropriate medication use. Rather, they address the biological foundations that make psychological interventions more effective. Some patients find their other care becomes more productive once physiological factors are addressed. Any change to a psychiatric medication should only be made with your prescribing clinician.
How Mental Wellness Care Works at The Longevity Centers
Mental wellness care at The Longevity Centers follows the same structured process used across the practice. The main stages include:
1. Initial intake visit
A licensed provider reviews your medical history, current concerns, and lifestyle factors, then orders laboratory testing based on that conversation.
2. Care plan
Your licensed provider reviews the results with you and builds an individualized plan, which may include a single mental wellness therapy or a combination.
3. Active treatment
Your care team monitors your response and adjusts the protocol as needed.
4. Progress evaluation
Key labs are retested at the end of the care window and compared with your original baseline, along with how you feel.
If anxiety, diminished mood, trauma-related symptoms, or persistent brain fog have not fully responded to conventional care, this process can help identify which physiological factors may be involved. Learn more about the LCOA process.
Where can I get Mental Wellness Therapies?
Our Florida and South Carolina care teams are ready to guide you through Mental Wellness Therapies, built around your goals.
Vida Building — Second Floor 1480 Hippocrates Way West Palm Beach, FL 33411
Frequently Asked Questions About Mental Wellness Therapies
What symptoms can mental wellness therapies help address?
These therapies are designed to support adults experiencing anxiety, low mood or depression, trauma-related symptoms, brain fog, burnout, and stress-related sleep problems, particularly when symptoms have not fully responded to conventional care. Because each therapy targets different physiological factors (nervous system overactivity, inflammation, or hormonal imbalance), the right fit depends on what may be driving an individual patient’s symptoms.
How does a stellate ganglion block work for PTSD and anxiety?
A stellate ganglion block delivers a local anesthetic to the stellate ganglion, a cluster of nerves in the neck that helps regulate the fight-or-flight response. Temporarily quieting these nerves is thought to reset an overactive stress response.
Is a stellate ganglion block safe?
Stellate ganglion block has been used for decades, primarily to treat pain conditions, and is generally considered low-risk when performed by a trained clinician with ultrasound guidance. Temporary effects are common and expected, such as a droopy eyelid, hoarseness, or warmth on one side of the face, and they typically fade as the anesthetic wears off. Your licensed provider will review your medical history and any individual risks before treatment.
What is the difference between IV ozone therapy, EBOO, and EBOOST™?
IV ozone therapy is the broad category of treatments that expose blood to medical ozone. EBOO (extracorporeal blood oxygenation and ozonation) is a more comprehensive form in which blood is drawn, filtered, exposed to oxygen and ozone, and returned to the body in a closed loop. EBOOST™ is a proprietary protocol developed by Dr. Benjamin Kosubevsky, D.O., lead physician at The Longevity Centers of America.
Do I need to stop my current medication or therapy?
Not at all. These therapies are designed to work alongside psychotherapy and prescribed medication, not in place of them. Some patients find that their existing treatment becomes more productive once physiological factors are addressed, but any change to a psychiatric medication should be made only with the prescribing clinician’s guidance.
How do I know which mental wellness therapy is right for me?
Care begins with an initial intake visit, during which a licensed provider reviews your symptoms, health history, and goals. Laboratory testing ordered at that visit, such as hormone testing, may help identify the physiological factors involved. Your licensed provider then builds a care plan around the results, which may include a single therapy or a combination.
Are these therapies appropriate during a mental health crisis?
These therapies are planned, non-emergency care and are not designed for crisis situations. If you or someone you know is in crisis or having thoughts of suicide, call or text 988 to reach the 988 Suicide and Crisis Lifeline, which is free and available 24 hours a day, or call 911 in an emergency.
References
- “Mental Health By the Numbers,” National Alliance on Mental Illness, retrieved on March 25, 2026, from: https://www.nami.org/mental-health-by-the-numbers/.
- Eduardo Ferat-Osorio, José Luis Maldonado-García, and Lenin Pavón, “How inflammation influences psychiatric disease,” World Journal of Psychiatry, March 2024, https://pmc.ncbi.nlm.nih.gov/articles/PMC11008389/.
- Mayank Mehrotra, Vamsi Reddy, and Paramvir Singh, “Neuroanatomy, Stellate Ganglion,” National Center for Biotechnology Information, National Library of Medicine, https://www.ncbi.nlm.nih.gov/books/NBK539807/.
- Jaimie Kerzner, Helen Liu, Ilya Demchenko, et al., “Stellate Ganglion Block for Psychiatric Disorders: A Systematic Review of the Clinical Research Landscape,” Chronic Stress, December 2021, https://pmc.ncbi.nlm.nih.gov/articles/PMC8664306/.
- Kristine L. Rae Olmsted, MSPH; Michael Bartoszek, MD; Sean Mulvaney, MD; et al., “Effect of Stellate Ganglion Block Treatment on Posttraumatic Stress Disorder Symptoms,” JAMA Psychiatry, November 2019, https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2753810.
- Nafiz K. Sheikh and Anterpreet Dua, “Procaine,” National Center for Biotechnology Information, National Library of Medicine, May 2023, https://www.ncbi.nlm.nih.gov/books/NBK551556/.
- Eda Gorbis, PHD, “Hormones, Mental Health and the Mind/Body Connection,” Anxiety & Depression Association of America, May 2023, https://adaa.org/learn-from-us/from-the-experts/blog-posts/professional/hormones-mental-health-and-mindbody.
- Jaideep Kapur and Suchitra Joshi, “Progesterone Modulates Neuronal Excitability Bidirectionally,” Neuroscience Letters, January 2022, https://pmc.ncbi.nlm.nih.gov/articles/PMC7821816/.